This Bubble Up Pizza Casserole recipe will become your favorite!

Ingredients
- 1 pound lean ground beef you can also use ground turkey or sausage for variation
- 1 small onion diced
- 2 cloves garlic minced
- 1 can 15 ounces pizza sauce
- 1 package 12 ounces refrigerated biscuit dough (such as Pillsbury Grands), cut into quarters
- 2 cups shredded mozzarella cheese
- 1 cup shredded cheddar cheese optional for extra cheesiness
- 1/2 cup sliced pepperoni you can also use other pizza toppings like bell peppers, mushrooms, olives, etc., according to your preference
- 1 teaspoon Italian seasoning
- 1/2 teaspoon garlic powder
- Salt and pepper to taste
- Cooking spray for greasing the baking dish
Instructions
- Preheat Oven: Start by preheating your oven to 375°F (190°C). Grease a 9×13-inch baking dish with cooking spray and set aside.
- Cook the Meat: In a large skillet over medium heat, cook the ground beef, onion, and garlic until the meat is browned and the onions are tender. Drain any excess fat.
- Combine Ingredients: To the skillet, add the pizza sauce, Italian seasoning, garlic powder, salt, and pepper. Stir to combine everything evenly. Then, gently fold in the quartered biscuit dough pieces, making sure they are coated with the sauce mixture.
- Layer in Baking Dish: Transfer half of the biscuit and meat mixture to the prepared baking dish. Sprinkle with half of the mozzarella and cheddar cheeses, and add a layer of pepperoni slices. Repeat the layers with the remaining biscuit mixture, cheese, and pepperoni.
- Bake: Place the baking dish in the preheated oven and bake for about 25-30 minutes, or until the biscuits have puffed up and turned golden brown, and the cheese is bubbly.
- Cool and Serve: Allow the casserole to cool for a few minutes before serving. This will make it easier to cut into portions and serve.
Frequently Asked Questions
Can I make Bubble Up Pizza Casserole ahead of time? Yes, you can assemble the casserole ahead of time and refrigerate it for up to a day before baking. Let it sit at room temperature for about 30 minutes before baking to ensure even cooking. You may need to adjust the baking time slightly if it’s cold from the fridge.
How do I store leftovers? Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. Reheat in the microwave or in the oven until heated through. The casserole can also be frozen for up to 2 months. Thaw overnight in the refrigerator before reheating.
Can I use homemade biscuit dough instead of store-bought? Absolutely! If you have a favorite biscuit recipe, you can use it in place of the refrigerated dough. Just ensure the dough is rolled or patted out to a similar thickness as the store-bought version to achieve the right cooking time and texture.
Is there a gluten-free option? For a gluten-free version, use a gluten-free biscuit dough and ensure that all your other ingredients, including the pizza sauce and toppings, are gluten-free. There are several brands of gluten-free biscuit dough available, or you can find recipes to make your own from scratch.